A difficult challenge lies in wait against the Latics, after their relegation from the Championship.
John Mousinho welcomes some players back to the fold, as they aim to make it 21 league games unbeaten at the DW Stadium.
Here’s how we think the Blues will line up against Shaun Maloney’s side.
9. Right wing: Paddy Lane
Reaching the form of his Fratton career - with goals coming, too. The pick of Pompey's wide attacking talent at present. Photo: Jason Brown
10. ACM: Alex Robertson
Is loving life at Pompey - and you can see that in his performances. Saydee is back in the equation, but Robertson deserves his starting spot. Photo: Jason Brown
11. LW: Abu Kamara
Still adjusting to the demands of League One football and its physicality, but has the ability to open up sides - as we've seen. Photo: Jason Brown
12. Striker: Colby Bishop
Five goals for the season and the form is there. Took a smash in the mouth last weekend against Lincoln, but going to take more than that to slow the Magic Man. Photo: Jason Brown