A difficult challenge lies in wait against the Latics, after their relegation from the Championship.
John Mousinho welcomes some players back to the fold, as they aim to make it 21 league games unbeaten at the DW Stadium.
Here’s how we think the Blues will line up against Shaun Maloney’s side.
13. Sub: Ryan Schofield
in the understudy position - and looks likely to stay there at present as Schofield waits for his chance. Photo: Jason Brown
14. Sub: Ryley Towler
For the sake of left-back cover, may make sense to go with Towler at the DW Stadium. Photo: Jason Brown
15. Sub: Zak Swanson
Certain to feel the love of the travelling Pompey fans, as the defender returns to the fray after the sad loss of his mother to cancer. Photo: Jason Brown
16. Sub: Terry Devlin
Made some really positive and important contributions off the bench - and the same may well be needed against the Latics. Photo: Jason Brown