A difficult challenge lies in wait against the Latics, after their relegation from the Championship.
John Mousinho welcomes some players back to the fold, as they aim to make it 21 league games unbeaten at the DW Stadium.
Here’s how we think the Blues will line up against Shaun Maloney’s side.
17. Sub: Tino Anjorin
Building his way into things after injury issues over the past year. Potential is clear - but also the need to manage his return. Photo: Jason Brown
18. Sub: Gavin Whyte
Pompey career yet to catch fire, but plenty of time for that to happen as he adjusts to his new surroundings on and off the pitch. Photo: Jason Brown
19. Sub: Christian Saydee
Welcome back to the Pompey favourite. Offers something Pompey don't have anywhere else with his ability to shake up opponents - may well be needed in a tough test. Photo: Jason Brown