A difficult challenge lies in wait against the Latics, after their relegation from the Championship.
John Mousinho welcomes some players back to the fold, as they aim to make it 21 league games unbeaten at the DW Stadium.
Here’s how we think the Blues will line up against Shaun Maloney’s side.
5. Centre-back: Conor Shaughnessy
Continues to fly under the radar - and continues to perform impressively when doing so. Photo: Jason Brown
6. Left-back: Jack Sparkes
A performance of extremes against Lincoln. Gave away the ball for the goal and had some shaky moments - but also some impressive contributions and outstanding delivery. Photo: Jason Brown
7. DCM- Marlon Pack
Has been a pillar of consistency this term and once again led by example. Photo: Jason Brown
8. DCM - Joe Morrell
Has to be THE form player for Pompey at the moment. Level has been ridiculously high in the past two games with his energy setting the bar for his team-mates. Photo: Jason Brown