The Blues’ League One promotion push has suffered a blow in their past two games, losing to rivals Hull and Lincoln.
With Pompey harbouring ambitions of a top-two finish, Kenny Jackett must find a way of delivering a result at an Addicks side also hoping to go up automatically.
The boss will be forced to make one change from the Lincoln defeat, with Jack Whatmough suspended for three games after receiving a red card.
But there could be temptation from Jackett to play some of his January recruits from the outset.
George Byers and Charlie Daniels both came off the bench against the Imps and there is growing clamour from sections of supporters for the pair to be given a chance.
Meanwhile, some fans also want to see Jordy Hiwula be given a crack after being left out of the past two squads.
Scroll down below to see how we think Pompey will line-up at The Valley…
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9. Left-midfield - Michael Jacobs
Ronan Curtis put in an almight shift against Lincoln and now started two games after recovering from coronavirus. Jacobs may then come into the side and look to be a key threat going forward. Photo: Joe Pepler
10. Striker - Ryan Williams
Pompey will surely look to get the energetic Aussie involved more so he can link-up with John Marquis after being isolated in recent games. Photo: PinPep
11. Striker - John Marquis
The 13-goal top scorer has been starved of service in the past two games and Kenny Jackett's admitted his side need to provide more support to Marquis. Photo: Joe Pepler
12. Sub 1 - Lewis Ward
The new signing from Exeter will go straight into the squad and take up deputy goalkeeping duties. Photo: Harry Trump