Pompey will be hoping for a change in fortune when they welcome Championship rivals Wrexham to Fratton Park tonight.
Both sides are sitting in the bottom half of the table ahead of their first league meeting since 1983 - but it is Blues who sit closest to the relegation zone in 20th-place, with John Mousinho’s men having just a four-point advantage on the bottom three.
For Wrexham, their motivation is clear as a win over Pompey would lift Phil Parkinson’s men into the top eight if results elsewhere fall in their favour.
Both Mousinho and Parkinson are already dealing with some key injury absentees that have hampered their attempts to build momentum this season - but what is the latest injury news from both sides as they prepare to face off on Wednesday night
Your next Portsmouth read: Update provided on 'absolute mountain' ahead of Portsmouth's game against Wrexham at Fratton Park
9. Franco Umeh
The Blues are yet to catch a glimpse of the £500,000 deadline day signing, who continues to be sidelined with a hamstring issue. Umeh is another absentee who has been pencilled in for the Millwall game. | Portsmouth FC Photo: Portsmouth FC
10. Thomas Waddingham - Out
The striker remains out after damaging a quad in training in September. The Aussie frontman is also scheduled to complete his comeback in time for the Fratton contest against Millwall. | ProSportsImages
11. Harvey Blair - Doubt
Mousinho has made it clear the Blues will be sensible over the winger’s comeback having felt his hamstring during the recent international break. | Graham Hunt/ProSportsImages
12. Jacob Farrell - Out
The luckless Australian returned to training last week, with Mousinho earmarking Saturday's visit to Birmingham as a potential return. Farrell was a no-show, however, and continues to have issues with his problematic groi injury. | Simon Roe/ProSportsImages