Pompey will be hoping for a change in fortune when they welcome Championship rivals Wrexham to Fratton Park tonight.
Both sides are sitting in the bottom half of the table ahead of their first league meeting since 1983 - but it is Blues who sit closest to the relegation zone in 20th-place, with John Mousinho’s men having just a four-point advantage on the bottom three.
For Wrexham, their motivation is clear as a win over Pompey would lift Phil Parkinson’s men into the top eight if results elsewhere fall in their favour.
Both Mousinho and Parkinson are already dealing with some key injury absentees that have hampered their attempts to build momentum this season - but what is the latest injury news from both sides as they prepare to face off on Wednesday night
Your next Portsmouth read: Update provided on 'absolute mountain' ahead of Portsmouth's game against Wrexham at Fratton Park
5. Danny Ward - Out
The Wales international goalkeeper is out of action until the new year after suffering a dislocated elbow last month. | Getty Images
6. Adrian Segecic - out
The Aussie sensation, who has netted three times for Pompey this term, currently remains absent due to an ankle issue suffered against Coventry City. Mousinho is hopeful the winger could return as early as Millwall later this month. | Graham Hunt/ProSportsImages
7. Andy Cannon - Out
The former Fratton Park miidfielder is still working his way back from an anterior cruciate ligament injury and will miss out on a reunion with Pompey. | Getty Images
8. Callum Lang - Out
Pompey fans are eager to see the return of the Fratton favourite, who has been a huge miss in the opening months of the campaign. Despite featuring in the Blues’ opening two matches of the season, the forward has been out since mid-August after undergoing hamstring surgery. Lang is expected to be back for the game against Millwall on November 22. | Jason Brown/ProSportsImages