John Mousinho’s men go into the contest above Southampton after a solid start to the season has seen them pick up seven points from their opening four games.
The Blues go into the derby in a much stronger position than the previous meeting against the Saints in 2019, with the two rivals meeting in the Carabao Cup third round.
Pompey, who were under the leadership of Kenny Jackett, faced Ralph Hassenhuttl’s Premier League Southampton, who sealed a 4-0 triumph. A Danny Ings double and goals from Cedric Soares and Nathan Redmond secured the victory over the League One Blues.
But where is Jackett’s side from that last meeting?
We’ve taken a look at where Pompey’s starting and bench was from the most recent south-coast derby.
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13. SUB 1: Alex Bass
After coming through the ranks at Fratton Park, Bass would later have spells at Sunderland, AFC Wimbledon and Notts County before joining Peterborough in the summer. The 27-year-old has made just one outing for Posh this term. | Getty Images
14. SUB 2: Anton Walkes
Walkes was a much-loved figure in the Pompey dressing room prior to his move to the MLS in 2020. The popular full-back tragically passed away in January 2023. | PinPep Media / Joe Pepler
15. SUB 3: Paul Downing
Downing went on to replace Hawkins at centre-back during the Southampton defeat, which would be just one of 27 appearances for the Blues during a three-year stay. The 33-year-old is without a club after being released by National League North side Kidderminster at the end of last season. | PinPep Media / Joe Pepler
16. SUB 4: Ross McCrorie
McCrorie spent the 2019-20 campaign on loan from Rangers at Fratton Park and amassed 23 appearances on the south coast. After a spell with Aberdeen, the Scotland international made the £2m to Bristol City in 2023, where he’s continued to impress. | PinPep Media / Joe Pepler