John Mousinho’s men go into the contest above Southampton after a solid start to the season has seen them pick up seven points from their opening four games.
The Blues go into the derby in a much stronger position than the previous meeting against the Saints in 2019, with the two rivals meeting in the Carabao Cup third round.
Pompey, who were under the leadership of Kenny Jackett, faced Ralph Hassenhuttl’s Premier League Southampton, who sealed a 4-0 triumph. A Danny Ings double and goals from Cedric Soares and Nathan Redmond secured the victory over the League One Blues.
But where is Jackett’s side from that last meeting?
We’ve taken a look at where Pompey’s starting and bench was from the most recent south-coast derby.
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17. SUB 5: Leon Maloney
Maloney was a surprise figure named on the bench to face Southampton having made his senior debut aged 17 prior to the derby. The winger totalled five appearances for the Blues before his 2020 exit. He now appears for the Hawks after joining in 2024. | Graham Hunt/ProSportsImages
18. SUB 6: Gareth Evans
The popular winger came on for the final 12 minutes against Southampton and was a huge fan-favourite prior to his 2020 exit. Evans has regularly appeared as a pundit on both Sky Sports and BBC Radio Solent covering the Blues. | PinPep Media / Joe Pepler