There’s a number of key issues for the Blues boss to consider, in a number of different areas of the pitch.
Are Regan Poole and Conor Shaughnessy ready to feature in the middle of the back line? Does Millenic Alli continue after a drop in form? Who plays in the No10 position? And does Mousinho keep faith with Colby Bishop?
Our Pompey writer Jordan Cross has weighed up the talking points - this is how he thinks the Pompey head coach will go.
17. Sub 5 Luke Le Roux
Midfield back-up likely the best of it for Le Roux at present. Photo: Graham Hunt
18. Sub 6 Adrian Segecic
Strong case to start Segecic as the No10 and could well be given a runout off the right flank. | Graham Hunt/ProSportsImages
19. Sub 7: Conor Chaplin
Has a role to play, but perhaps not from the start in this one. | Simon Roe/ProSportsImages
20. Sub 8: Harvey Blair
Could be needed to pep things up if Pompey are chasing the game. | Simon Roe/ProSportsImages