There’s a number of key issues for the Blues boss to consider, in a number of different areas of the pitch.
Are Regan Poole and Conor Shaughnessy ready to feature in the middle of the back line? Does Millenic Alli continue after a drop in form? Who plays in the No10 position? And does Mousinho keep faith with Colby Bishop?
Our Pompey writer Jordan Cross has weighed up the talking points - this is how he thinks the Pompey head coach will go.
13. Sub 1: Josef Bursik
Back-up role to Schmid will be assumed as usual. | Stephen Flynn/ProSportsImages
15. Sub 3 Jordan Williams
Not started a game since December, but closer to doing so after Devlin's struggles on Tuesday. Photo: Graham Hunt
16. Sub 4 Conor Shaughnessy
Won't be considered for more than one game in a week, with a place on the bench the likely role on Monday. | Graham Hunt/ProSportsImages