There’s a number of key issues for the Blues boss to consider, in a number of different areas of the pitch.
Are Regan Poole and Conor Shaughnessy ready to feature in the middle of the back line? Does Millenic Alli continue after a drop in form? Who plays in the No10 position? And does Mousinho keep faith with Colby Bishop?
Our Pompey writer Jordan Cross has weighed up the talking points - this is how he thinks the Pompey head coach will go.

1. Pompey v Derby predicted line-up
Here's how we think the Blues will line up against Derby | Iconic Media

2. GK Nicolas Schmid
Not much the Austrian could do about the goals against Swansea City on Tuesday night. | Getty Images

3. RB Terry Devlin
Tough night against Eom Ji-sung Tuesday, which showed Devlin's right-back education is continuing. | Dennis Goodwin/ProSportsImages

4. CB: Regan Poole
Welcome back to the man who's simply going to be critical to Pompey's defensive resolve from here on in. | Simon Roe/ProSportsImages