There’s a number of key issues for the Blues boss to consider, in a number of different areas of the pitch.
Are Regan Poole and Conor Shaughnessy ready to feature in the middle of the back line? Does Millenic Alli continue after a drop in form? Who plays in the No10 position? And does Mousinho keep faith with Colby Bishop?
Our Pompey writer Jordan Cross has weighed up the talking points - this is how he thinks the Pompey head coach will go.
5. CB Connor Ogilvie
Looks like the centre-back position will be his for the majority of the rest of the season, following this week's update over Conor Shaughnessy's availability. | Simon Roe/ProSportsImages
6. LB Zak Swanson
Came through some testing moments on Tuesday night to get stronger as the game went on against Swansea. | Dennis Goodwin/ProSportsImages
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7. CM Ebou Adams
Can't overstate how important this man is to Pompey's bid to stay in the Championship. | Simon Roe/ProSportsImages
8. CM: Marlon Pack
Not many people would've thought Pack would've been starting six games on the spin at this stage last season, but continues to carry the charge for Pompey. | Simon Roe/ProSportsImages