The Blues are aiming for successive victories after defeating Charlton Athletic 3-1 at The Valley on Tuesday evening.
And they’re looking to bounce back to success on their own patch following losses to Hull City and Lincoln last month.
Pompey’s automatic promotion push is being hampered by their form at PO4, having also lost to Wigan, Doncaster and Charlton this season.
What’s more, they face a Plymouth side who are unbeaten in their past five league games and recently beat Sunderland on their travels.
Kenny Jackett must weigh up which starting XI he believes will be best to defeat the Pilgrims.
The Blues boss made four changes at The Valley, although James Bolton replacing Jack Whatmough was enforced because of the latter’s suspension.
Scroll down and click through the pages to see how we think Pompey will line-up and who’ll be named among the substitutes.
13. Sub 2 - Lee Brown
Very unlucky to lose his starting spot at Charlton. A superb option on the bench nonetheless. Photo: Joe Pepler
14. Sub 3 - Harvey White
Still awaits his first start after arriving on loan from Tottenham last month. Came off the bench late at Charlton. Photo: PinPeP
15. Sub 4 - George Byers
Came to Fratton Park for regular minutes after his injury nightmare at Swansea. However, Byers can have few complaints he's been on the bench in the past two games given the form of Tom Naylor and Andy Cannon. Photo: Joe Pepler
16. Sub 5 - Ronan Curtis
Must be patient for his next chance and capable of making an impact from the bench. Photo: Joe Pepler