The Blues are aiming for successive victories after defeating Charlton Athletic 3-1 at The Valley on Tuesday evening.
And they’re looking to bounce back to success on their own patch following losses to Hull City and Lincoln last month.
Pompey’s automatic promotion push is being hampered by their form at PO4, having also lost to Wigan, Doncaster and Charlton this season.
What’s more, they face a Plymouth side who are unbeaten in their past five league games and recently beat Sunderland on their travels.
Kenny Jackett must weigh up which starting XI he believes will be best to defeat the Pilgrims.
The Blues boss made four changes at The Valley, although James Bolton replacing Jack Whatmough was enforced because of the latter’s suspension.
Scroll down and click through the pages to see how we think Pompey will line-up and who’ll be named among the substitutes.
1. Goalkeeper - Craig MacGillivray
The Scot delivered another commanding performance at Charlton on Tuesday. Showed new-keeper Lewis Ward why he is firmly No1 at PO4. Photo: PinPeP
2. Right-back - Callum Johnson
Another resolute performance from the ex-Accrington man at Charlton as he continues to prove his worth. Photo: Joe Pepler
3. Centre-back - James Bolton
A magnificent performance from the ex-Shrewsbury man on his first league appearance of the season at Charlton. With Rasmus Nicolaisen set to again be absent and Jack Whatmough suspended, Bolton will keep his spot. Photo: Nigel Keene
4. Centre-back - Sean Raggett
The fearless defender made block after block at Charlton, typifying the sort of player he is. One of the first names on the team sheet. Photo: Joe Pepler