Chiefly the Blues boss has to decide whether to go with John Marquis or George Hirst at Adams Park.
Hirst staked his claim with a man-of-the-match performance on Tuesday night as Marquis continues to struggle for form.
Elsewhere, there’s Arsenal’s Miguel Azeez pushing for a start with Cowley admitting he could be down to as few as 14 fit senior players.
Here’s how we believe the Pompey boss will line up as they face a tough test at the high-flying Chairboys.
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2. Alex Bass
Rare chance to make a mark With Gavin Bazunu on international duty Photo: The News

3. Mahlon Romeo
Lookes nailed on for the right-back berth ahead of Kieron Freeman. Photo: The News

4. Sean Raggett
Remains among Pompey's best and most consistent performers this season. Photo: The News