Chiefly the Blues boss has to decide whether to go with John Marquis or George Hirst at Adams Park.
Hirst staked his claim with a man-of-the-match performance on Tuesday night as Marquis continues to struggle for form.
Elsewhere, there’s Arsenal’s Miguel Azeez pushing for a start with Cowley admitting he could be down to as few as 14 fit senior players.
Here’s how we believe the Pompey boss will line up as they face a tough test at the high-flying Chairboys.
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5. Connor Ogilvie
Has really settled the Pompey defence down since coming in the left of the central pairing. Photo: The News
6. Lee Brown
Will have the armband as he aims to continue dependable form. Photo: The News
7. Shaun Williams
Form has fluctuated of late but will get the nod with Morrell away with Wales. Photo: The News
8. Louis Thompson
Withdrawn at the break on Tuesday with this game in mind. Definite starter. Photo: The News