Following comprehensive wins at Gillingham and Sunderland, the Blues are tasked with continuing their fine progress following an indifferent start to the season.
Kenny Jackett will be forced into making one change to his starting line-up, with Michael Jacobs ruled out injured for up to six weeks.
But will the Pompey boss opt to make any other adjustments to his side? Take a look at how we think the Blues will start and who will be on the bench below.
9. Left-midfield - Ronan Curtis
The Irishman has a big opportunity with Michael Jacobs out injured. Has the ability to bounce back, having been one of Pompey's start performers in the past few seasons. Photo: Joe Pepler
10. Striker - Marcus Harness
Really made the role his own and continues to get better leading the line. Will be looking to add to his six goals already this season. Photo: Daniel Chesterton
11. Striker - John Marquis
Relished having a strike partner in recent games with three goals. Will make it difficult for Jordy Hiwula or Ellis Harrison to win a starting spot when both are up to speed if he continues the way he's going. Photo: Joe Pepler
12. Sub 1 - Alex Bass
Continues to remain patient after dropping down the pecking order. Photo: Nigel Keene