Following comprehensive wins at Gillingham and Sunderland, the Blues are tasked with continuing their fine progress following an indifferent start to the season.
Kenny Jackett will be forced into making one change to his starting line-up, with Michael Jacobs ruled out injured for up to six weeks.
But will the Pompey boss opt to make any other adjustments to his side? Take a look at how we think the Blues will start and who will be on the bench below.
5. Left-back - Lee Brown
Nailed down the spot ahead of Bristol City loanee Cam Pring. Experience and nous has been crucial, along with his set-pieces. Photo: PinPeP
6. Right-midfield - Ryan Williams
Has made the role his own in the 4-4-2 system. Got himself a 'second' assist at Sunderland, as well as winning the penalty. Photo: Joe Pepler
7. Centre-midfield - Tom Naylor
Been at his best in recent games and remains one of the first names on the team sheet. Photo: Joe Pepler
8. Centre-midfield - Andy Cannon
The switch to a two-man central midfield has got the best out of the former Rochdale man. Photo: Joe Pepler