Following comprehensive wins at Gillingham and Sunderland, the Blues are tasked with continuing their fine progress following an indifferent start to the season.
Kenny Jackett will be forced into making one change to his starting line-up, with Michael Jacobs ruled out injured for up to six weeks.
But will the Pompey boss opt to make any other adjustments to his side? Take a look at how we think the Blues will start and who will be on the bench below.
13. Sub 2 - Haji Mnoga
The youngster has been serving as 19th man recently. With Michael Jacobs injured, this could be an opportunity to put him on the bench. Photo: Jason Brown
14. Sub 3 - Rasmus Nicolaisen
The Dane continues to serve as back-up. Despite clamouring from supporters for him to play, it's proving hard to drop Jack Whatmough or Sean Raggett so far. Photo: Nigel Keene
15. Sub 4 - Cam Pring
Should Haji Mnoga serve on the bench, Pring could be regarded as an option to play further forward if he's required. Photo: Joe Pepler
16. Sub 5 - Bryn Morris
Fallen out of favour after starting the opening five league games. Photo: PinPeP