After impressive wins over Gillingham, Sunderland and Northampton, confidence is riding high in the Blues camp going into the game.
But the same can be said for the Addicks, having triumphed in their past four league games.
It proves to be an intriguing clash and Kenny Jackett will once again have to get his team and tactics spot on to pick up a success.
But will the Pompey boss make any changes to his starting XI? And will he shuffle his bench? We take a look at the likely match-day 18...
9. Left-wing - Ronan Curtis
Notched his first league goal against Northampton and hopefully that can be the springboard he neets to recapture his form of the past two seasons. Photo: Joe Pepler
10. Striker - Marcus Harness
Been in rampant goalscoring form and will surely be shortlisted for Player of the Month for October. Photo: Daniel Chesterton
11. Striker - John Marquis
Five goals in three games, the ex-Doncaster man is in excellent form in the final third. Photo: Pete Norton
12. Sub 1 - Alex Bass
Having to bide his time after serving as No1 during the second half of last season. Photo: Nigel Keene