The Royal Navy’s future flagship departed from her home at the naval base on Wednesday afternoon.
She was initially due to leave on Monday, however a Covid-19 outbreak among her crew pushed it back two days.
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Hundreds of people lined the harbour walls in Old Portsmouth to give the carrier a proper send off.
HMS Queen Elizabeth is continuing the preparations for her maiden operational mission in 2021.
She will return to Portsmouth next week to take on stores before departing again.
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9. HMS Queen Elizabeth
A person takes a photograph as HMS Queen Elizabeth leaves Portsmouth. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
10. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth on September 9. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
11. HMS Queen Elizabeth
Merlin helicopters on the flight deck of the Royal Navy aircraft carrier HMS Queen Elizabeth. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
12. HMS Queen Elizabeth
Crew members stand outside one of the two islands on the flight deck as HMS Queen Elizabeth leaves Portsmouth. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews