The Royal Navy’s future flagship departed from her home at the naval base on Wednesday afternoon.
She was initially due to leave on Monday, however a Covid-19 outbreak among her crew pushed it back two days.
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Hundreds of people lined the harbour walls in Old Portsmouth to give the carrier a proper send off.
HMS Queen Elizabeth is continuing the preparations for her maiden operational mission in 2021.
She will return to Portsmouth next week to take on stores before departing again.
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1. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth on 9 September 2020. Pictured: View from Still & West Pub, Portsmouth of HMS QE. Picture: Habibur Rahman Photo: Habibur Rahman
2. HMS Queen Elizabeth
Helicopters pictured on the flight deck of HMS Queen Elizabeth as she sails from Portsmouth on September 9. Picture: Habibur Rahman Photo: Habibur Rahman
3. HMS Queen Elizabeth
HMS Queen Elizabeth pictured with a Merlin helicopter on her flight deck as she departed Portsmouth on September 9. Picture: Habibur Rahman Photo: Habibur Rahman
4. HMS Queen Elizabeth
A crew member stands next to a Merlin helicopter on the flight deck of HMS Queen Elizabeth as she leaves Portsmouth on September 9. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews