The Royal Navy’s future flagship departed from her home at the naval base on Wednesday afternoon.
She was initially due to leave on Monday, however a Covid-19 outbreak among her crew pushed it back two days.
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Hundreds of people lined the harbour walls in Old Portsmouth to give the carrier a proper send off.
HMS Queen Elizabeth is continuing the preparations for her maiden operational mission in 2021.
She will return to Portsmouth next week to take on stores before departing again.
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5. HMS Queen Elizabeth
People wave from the Round Tower in Old Portsmouth as HMS Queen Elizabeth departs. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
6. HMS Queen Elizabeth
Crew members stand outside as HMS Queen Elizabeth leaves Portsmouth on September 9. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
7. HMS Queen Elizabeth
A Royal Navy officer and a member of the US Marines stand next to a Merlin helicopter on the flight deck of HMS Queen Elizabeth. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews
8. HMS Queen Elizabeth
HMS Queen Elizabeth leaves Portsmouth Naval Base as it sets sail for flight trials. Picture: Andrew Matthews/PA Wire Photo: Andrew Matthews