Interim head coach Simon Bassey has the task of pulling off a huge shock as his side are roared on by 8,800 travelling fans in the capital.
Pompey are decimated by suspension, players unavailable and injury for the clash – making how they line up even more fascinating than ever.
Here’s how we think they will go at the Tottenham Hotspur Stadium.
17. Sub 6 - Reeco Hackett
Close call whether he will start or be on the bench. Photo: Jason Brown
18. Sub 7 - Michael Jacobs
A player like Jacobs who can keep the ball may well be a key player off the bench. Photo: Jason Brown
19. Sub 8 - Josh Koroma
Pace could be a useful asset either from the outset or to help when legs tire. Photo: Jason Brown
20. Sub 9 - Joe Pigott
Started against Charlton but failed to make an impact, so could well be back on the bench. Photo: Jason Brown
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