Interim head coach Simon Bassey has the task of pulling off a huge shock as his side are roared on by 8,800 travelling fans in the capital.
Pompey are decimated by suspension, players unavailable and injury for the clash – making how they line up even more fascinating than ever.
Here’s how we think they will go at the Tottenham Hotspur Stadium.
13. Sub 2 :Josh Dockerill
What a day it could be for the young academy defender. Photo: Simon Davies
14. Sub 3 - Kieron Freeman
Back from his calf problems and likely to be on the bench. Photo: Graham Hunt
15. Sub 4: Adam Payce
A place on the bench could be the academy talent's reward for his hard work and progress this season. Photo: Sarah Standing
16. Sub 5 - Louis Thompson
What a sight it will be to see Thompson on the bench after five months out with a broken leg! Photo: Jason Brown
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