Interim head coach Simon Bassey has the task of pulling off a huge shock as his side are roared on by 8,800 travelling fans in the capital.
Pompey are decimated by suspension, players unavailable and injury for the clash – making how they line up even more fascinating than ever.
Here’s how we think they will go at the Tottenham Hotspur Stadium.

5. Zak Swanson - right wing-back
The former Gooner can expect a friendly welcome at the Tottenham Hotspur Stadium. Photo: Jason Brown

6. Joe Morrell - centre midfield
Plenty will rest on the shoulders of the Wales international, who has been in good form of late. Photo: Jason Brown

7. Jay Mingi - Centre midfield
Big moment in the promising midfielder's career. Capable of shining on the big stage. Photo: Jason Brown

8. Denver Hume - left-wing-back
Will need every once of his energy up and down the left flank - along with his undoubted crossing ability. Photo: Jason Brown

