But despite the Blues’ proud record in the competition in recent seasons – and Posh’s decision to go stronger than expected for the last-16 tie – Kenny Jackett is set to reshuffle his pack for the game at London Road.
The News has been told that none of the starting XI involved at Bristol City on Sunday will kick-off tonight’s fixture, which means an entirely line-up will take the field.
It will no doubt be a blend of youth and experience – as has been the case for all of Pompey’s Trophy games this season.
But who will Jackett call upon?
Well, here’s who we think will start…
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9. Charlie Bell - attacking midfield
The 18-year-old midfielder has made such a impression in this year's competition that it would be only natural for him to be given another run-out to continue his development. Photo: Robin Jones
10. Jordy Hiwula - left-wing
The forward won't like being put out on the wing, but he desperately needs the game time. Signed a new contract with the Blues last month and will be desperate to show Kenny Jackett that he deserves more league minutes - if not a starting place against Fleetwood on Saturday. Photo: Nigel Keene
11. Ellis Harrison - centre-forward
The striker really needs to start showing that he's capable of leading the line on a more regular basis. Has scored only three goals in 17 appearances, so tonight's game represents a huge test of his credentials. Will be hoping to make the most of his opportunity, with Hiwula also breathing down his neck. Photo: Jason Brown