Pompey will be looking to keep up their impressive home league record against their foes along the M27, who haven’t won in league action at PO4 for 50 years.
But how does John Mousinho aim to come out on top, amid his side’s injury crisis with 10 players sidelined?
Here’s how Pompey writer Jordan Cross think’s he’ll go in the high noon showdown at Fratton Park.
5. CB Connor Ogilvie
Really stood up at Watford with a display which eased the pain of Conor Shaughnessy's loss. Definitely the best solution to centre-back woes at present. Photo: Graham Hunt
6. LB Jordan Williams
With Zak Swanson struggling at Watford, Williams was introduced and impressed with his energy at Vicarage Road. On that evidence, he did enough to retain his place in the side. Photo: Graham Hunt
7. CM Ebou Adams
Has all the attributes to become a fans' favourite and a player who will be expected to thrive in the heat of a Fratton derby. Photo: Portsmouth FC
8. CM Andre Dozzell
Industry will be key against the quality Southampton possess in the middle of the park. Photo: Graham Hunt