Pompey will be looking to keep up their impressive home league record against their foes along the M27, who haven’t won in league action at PO4 for 50 years.
But how does John Mousinho aim to come out on top, amid his side’s injury crisis with 10 players sidelined?
Here’s how Pompey writer Jordan Cross think’s he’ll go in the high noon showdown at Fratton Park.
1. Predicted Pompey line-up
Here's how we think Pompey will line up against Southampton. | Stephen Flynn/ProSportsImages
2. GK: Nicolas Schmid
Gaffe to forget at Watford, with keeper needing to bounce back now - and his record suggests he wll. | Getty Images
3. RB Terry Devlin
The one-man riot is made for these occasions. Pompey fans will be looking forward to seeing him get stuck into rivals. Photo: Graham Hunt
4. CB Regan Poole
Quite possibly Pompey's most important player now amid centre-back injury woes. | Graham Hunt/ProSportsImages