The fixture, which will be broadcasted live on Sky Sports and ITV, is set to be the first league meeting between the two sides at PO4 since February 2012.
Callum Lang netted a double in West Yorkshire back in August, but John Mousinho won’t be able to call on his top scorer as he remains sidelined for the remainder of the campaign through injury.
While the head coach has to contend with a growing injury list, the prospect of facing top-of-the-table Leeds is something else as Daniel Farke’s juggernaut continue their bid for promotion and are unbeaten in their previous 17 league games - dating back to November.
However, Fratton Park will be close to a sell-out on Sunday lunchtime, with the Blues themselves utilising home advantage to drag them away from the relegation dogfight. Pompey have lost just once in their past 11 games on home soil, with that defeat coming against Millwall in January.
It’s fascinating contest is in store this weekend, with both sides fighting crucial battles at either ends of the table.
We’ve taken a look at the injury news for both sides ahead of Sunday’s game.
9. Hayden Matthews - out
The January arrival becomes the latest member of Mosuinho’s squad to be ruled out for the campaign after the club announced last week he would require surgery on his ankle, with the injury sustained against QPR. | National World
10. Rob Atkinson - out
The Bristol City loanee has featured 10 times since his switch from Ashton Gate in January but was ruled out for 6-8 weeks after picking up a calf problem against QPR two-weeks ago. | National World
11. Conor Shaughnessy - out
Shaughnessy has been absent since mid-February after sustaining a hamstring issue against Cardiff. After being set a six-to-eight week timeframe for his comeback, Mousinho has targeted a return to training for the centre-back at the end of the month. Pic: Jason Brown/ProSportsImages | Jason Brown/ProSportsImages
12. Jordan Williams - out
The right-back has been absent since January with a hamstring issue and isn’t expected to return against Leeds. Mousinho has pencilled in a return date against Blackburn on March 29 for Williams. Picture: Jason Brown/ProSportsImages | The News