The fixture, which will be broadcasted live on Sky Sports and ITV, is set to be the first league meeting between the two sides at PO4 since February 2012.
Callum Lang netted a double in West Yorkshire back in August, but John Mousinho won’t be able to call on his top scorer as he remains sidelined for the remainder of the campaign through injury.
While the head coach has to contend with a growing injury list, the prospect of facing top-of-the-table Leeds is something else as Daniel Farke’s juggernaut continue their bid for promotion and are unbeaten in their previous 17 league games - dating back to November.
However, Fratton Park will be close to a sell-out on Sunday lunchtime, with the Blues themselves utilising home advantage to drag them away from the relegation dogfight. Pompey have lost just once in their past 11 games on home soil, with that defeat coming against Millwall in January.
It’s fascinating contest is in store this weekend, with both sides fighting crucial battles at either ends of the table.
We’ve taken a look at the injury news for both sides ahead of Sunday’s game.
5. Jacob Farrell - out
The left-back has featured just once this season but remains sidelined for the rest of the campaign with a knee injury. | Jason Brown/ProSportsImages
6. Ibane Bowat - out
Following his arrival from Fulham in the summer transfer window, the central defender has appeared in just one Blues squad having subsequently been ruled out for the season with a knee issue. | Portsmouth FC
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7. Callum Lang - out
Pompey’s top scorer netted twice against Leeds on the opening day of the season but will have to watch on from the sidelines after his campaign was brought to a premature end when he sustained a hamstring issue against Oxford United last month. | Jason Brown/ProSportsImages
8. Paddy Lane - out
The winger picked up a knee injury against Blackburn in January and is another to miss the remainder of the season. | National World