New boss Frank Lampard brings his side to PO4 after succeeding Mark Robins at the end of November.
Pompey have fitness and form issues to contend with going into the game, at the start of five fixtures in 16 days.
Here’s how we think John Mousinho’s side will line up ahead of the clash.
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13. Sub 1: Jordan Archer
Looks to be favoured for the sub keeper role with Will Norris' future under the microscope. | The News
14. Sub 2: Terry Devlin
Been a real find at right-back but had a tough night at Derby. Could be the right time for a rest with games coming thick and fast. Photo: Jason Brown
15. Sub 3: Tom McIntyre
Having a tough time at the moment after looking like form had picked up. A close call now between McIntyre and Towler. | Jason Brown/ProSportsImages
16. Sub 4: Owen Moxon
Close to being a starter after a losing his spot following a decent Norwich showing - Dozzell and Potts didn't excel in his Derby absence. | Jason Brown/ProSportsImages