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Does he keep faith with a side that battled back so impressively to get a draw out of Saturday’s trip to Hul? Or does he freshen his side up for the second of successive away games four days apart?
The way the Blues have started both their midweek Championship games this season against Stoke and Cardiff respectively suggests the latter might be the best approach. Indeed, Pompey’s two worst performances of the season so far came at the bet365 and City of Cardiff stadiums.
Yet Mousinho admitted on Monday that there’s a different vibe in his ranks ahead of the Plymouth game and that Saturday’s second-half performance at Hull has provided momentum that he’s keen to make the most of.
That suggests changes will be kept to a minimum - or even just the one as the Blues look to get a result against a Plymouth squad dealing with a host of injuries and on currnetly a run of three defeats from four games.
So what can we expected selection-wise tonight? Well, this is how we believe the Blues will line up at Home Park.
9. Right-wing - Matt Ritchie
The former Newcastle favourite justified his starting berth against Hull as he produced the type of performance we've all been dying to see since his Fratton Park return in the summer. November 2021 was the last time the 33-year-old has started back-to-back games. That will be a concern ahead of tonight's visit to Home Park - but taking him out of the starting XI at Plymouth would be a crime! | National World
10. No10 - Callum Lang
The one and only contender for Pompey player of the season so far. Say's it all, really! | National World
11. Left-wing - Josh Murphy
His equaliser 20 seconds into the second half at Hull will have boosted his confidence no end - and help silence some of his critics. It's just a pity Tigers keeper Ivan Pandur denied him a second in injury time. | National World
12. Striker - Mark O'Mahony
The on-loan Brighton striker was named on the bench for the trip to Hull. That was partly put down to tiredness as the 19-year-old enjoys his first full season at senior level. However, he could be back to lead the line at Plymouth tonight after being handed a breather and following Kusini Yengi's below-par performance at the MKM Stadium. | National World