The Blues have an injury doubt in Marlon Pack heading into the game, with the club captain nursing an ankle injury from Saturday’s win against Wigan.
Connor Ogilvie, Anthony Scully, Kusini Yengi and Tom Lowery also remain out, leaving John Mousinho with a bit of a selection headache.
But with the Blues in impressive form this season and having plenty of options within the squad to chose from, there’s no need to panic.
Here’s how we believe the Blues will line up tonight, despite the absence of some key players.
5. Centre-back 2: Conor Shaughnessy
Bearing in mind Shaughnessy arrived in the summer to act as back-up to Poole, Sean Raggett and Ryley Towler, it's testament to him that he hasn't looked back after being handed his league debut at Stevenage. Has been an ever-present since that golden opportunity and is forming a good understanding with Poole Photo: Jason Brown
6. Left-back: Jack Sparkes
Is proving a good deputy for the injured Connor Ogilive, after demonstrating some initial nerves. Wil continue to deputise as Pompey wait for Ogilvie to return. Photo: Jason Brown
7. Central midfield 1: Joe Morrell
The Welshman will have a key part to play if Marlon Pack is forced to sit the Wycombe game out through injury. He's always in the thick of it at the best of times. That will again be crucial tonight - as will the need to keep a calm head. His experience will be key. Photo: Jason Brown
8. Central midfield 2: Alex Robertson
There's a good chance Marlon Pack will have to sit the Wycombe game out following that challenge from Charlie Wyke on Saturday. He'll be missed against the Chairboys. But in Alex Robertson, Pompey have a player who is growing in confidence with every game. Produced a man-of-the-match display against Wigan by playing higher up the pitch. Yet he's more than capable of dropping back and sitting in, too. Seems the obvious choice to fill the Pack void rather than the underused Ben Stevenson and Terry Devlin, who is yet to start a league game for the Blues, despite encouraging displays from the bench. Photo: Jason Brown