Victory would be another sign of the progress currently being made by head coach Danny Cowley in his second full season in charge at Fratton Park.
And while the unbeaten Blues go into the game as pre-match favourites, the manager remains intent on handing his fringe players and youngsters the chance to get vital minutes into their legs.
That is likely to see wholesale changes made to the side that beat Bristol Rovers 3-1 in the league in Saturday.
And with the hosts favouring a 3-5-2 formation, it would even see the visitors switching systems to go head-to-head with the League Two outfit.
And no, it wouldn’t be a direct response to Cowley’s favoured 4-4-2 formation which was criticised by Gas boss Joey Barton at the weekend.
Here’s how we think, Pompey could line up tonight at Rodney Parade.
That is likely to see wholesale changes made to the side that beat Bristol Rovers 3-1 in the league in Saturday.
![Despite featuring in all six of Pompey's games to date, the forward has only two starts to his name. He could be given a rare place in the starting XI as he looks to establish himself more. Remains a player Danny Cowley has a lot of admiration for.](https://www.portsmouth.co.uk/webimg/b25lY21zOmE5NDE4NjczLTA1ZDYtNDViMC1iNzllLTcxOWFjYjM3NWUyZDpmYTVlN2I5NC1lNGJjLTRhNDgtYmI4My02Yzk1MDFiN2UzOTc=.jpg?crop=3:2&trim=&width=640)
9. Reeco Hackett
Despite featuring in all six of Pompey's games to date, the forward has only two starts to his name. He could be given a rare place in the starting XI as he looks to establish himself more. Remains a player Danny Cowley has a lot of admiration for.Photo: NationalWord
![The young Spurs loanee has looked hugely impressive since arriving at Pompey, with his assist for Owen Dale's goal a perfect reminder of his capabilities. He's yet to open his own Blues goal account though. Could tonight finally be the night?](https://www.portsmouth.co.uk/webimg/b25lY21zOmJhOWM1ZmUwLTljOTgtNGNhYi1hMjgzLTk2MWQxZTBlYTY2Njo0YTFlNTQxOC05YzA2LTRmYTgtYWZkNC1hMTc4OGU2YzEyOTk=.jpg?crop=3:2&trim=&width=640)
10. Dane Scarlett
The young Spurs loanee has looked hugely impressive since arriving at Pompey, with his assist for Owen Dale's goal a perfect reminder of his capabilities. He's yet to open his own Blues goal account though. Could tonight finally be the night?Photo: NationalWorld
![The striker's last start came in the first-round win against Cardiff, with the on-loan Ipswich man having to make do with a place on the bench since. He remains a team player, though, and he should get his reward with a return to the starting XI tonight. Has two goals and one assist since joining the Blues.](https://www.portsmouth.co.uk/webimg/b25lY21zOjE4NjgyMTZlLWRkZDMtNDc2NS05ODAwLWM1Y2UwODVjMDU5NzphYWZkMTUxMC01NzljLTRkZjItYTdlNy03OTBhMjNlNGQ4NTk=.jpg?crop=3:2&trim=&width=640)
11. Joe Pigott
The striker's last start came in the first-round win against Cardiff, with the on-loan Ipswich man having to make do with a place on the bench since. He remains a team player, though, and he should get his reward with a return to the starting XI tonight. Has two goals and one assist since joining the Blues.Photo: Nationalworld