Victory would be another sign of the progress currently being made by head coach Danny Cowley in his second full season in charge at Fratton Park.
And while the unbeaten Blues go into the game as pre-match favourites, the manager remains intent on handing his fringe players and youngsters the chance to get vital minutes into their legs.
That is likely to see wholesale changes made to the side that beat Bristol Rovers 3-1 in the league in Saturday.
And with the hosts favouring a 3-5-2 formation, it would even see the visitors switching systems to go head-to-head with the League Two outfit.
And no, it wouldn’t be a direct response to Cowley’s favoured 4-4-2 formation which was criticised by Gas boss Joey Barton at the weekend.
Here’s how we think, Pompey could line up tonight at Rodney Parade.
5. Zak Swanson
The Arsenal Academy product will likely to be given a rare start after having to watch Joe Rafferty establish himself as Danny Cowley's first-choice right-back. Has looked decent on the two occasions he's featured this season and the manager will want to get more minutes into his legs. Photo: National World
6. Marlon Pack
Pompey need to careful in midfield given Louis Thompson's injury. But they do have strength in numbers there and with Jay Mingi likely to earn the chance to start, Pack's experience will prove important. Doubt he'll play the whole game, though. Photo: NationalWorld
7. Jay Mingi
The midfielder can count himself unlucky to not make the match-day stay for Saturday's visit of Bristol Rovers. Joe Morrell's return from injury will also do the youngster no favours. But Cowley is a bit admirer of the former West Ham and Charlton youngster and will likely utilise him from the start against Newport, with maybe Morrell joining him in the second half. Photo: National World
8. Denver Hume
If ever a player needed match minutes, it's Hume. The former Sunderland man hasn't featured for Pompey since mid-March because of a back injury. He's a lot of catching up to do and tonight could be the ideal opportunity to begin the comeback trail. Photo: National World