The Blues may be condemned to a seventh successive season in League One, but there will still be 3,000-plus travelling fans making the trip to Pride Park.
It may be a meaningless game to Pompey but there’s everything riding on it for Paul Warne’s men, with three points a must for their play-off ambitions.
Here’s how we think John Mousinho will play it, as his side aim to give some reasons to be cheerful with the campaign nearing a close.
13. SUB: Josh Oluwayemi
Likely to be here next season and building his reputation. Photo: Jason Brown
14. Sean Raggett
Mousinho's consideration has to be does he want his young partnership to face a strong test of their credentials, or opt for Raggett's nous and strength? Photo: Jason Brown
15. SUB - Clark Robertson
Like Raggett, may be a call to turn to one of the experienced central defenders at least - but wouldn't go down well with the punters, who love Towler. Photo: Jason Brown
16. SUB: Harry Jewitt-White
Really impressed last weekend on his full league bow, but Mousinho likely to stiffen things up against powerful opposition. Photo: Jason Brown