The Blues may be condemned to a seventh successive season in League One, but there will still be 3,000-plus travelling fans making the trip to Pride Park.
It may be a meaningless game to Pompey but there’s everything riding on it for Paul Warne’s men, with three points a must for their play-off ambitions.
Here’s how we think John Mousinho will play it, as his side aim to give some reasons to be cheerful with the campaign nearing a close.
5. CB Ryley Towler
Would be interesting to see how the defender deals with a big occasion and a potent Derby attack, with an eye to the future. Photo: Jason Brown
6. LB - Connor Ogilvie
Certain to start and very likely to be here next term. Photo: Jason Brown
7. CM: Marlon Pack
Could've joined Derby, so will look to make an impact at Pride Park. Photo: Jason Brown
8. CM: Tom Lowery
After a stop-start season will be looking to finish strongly. Photo: Jason Brown