The Blues are dealing with extensive injury issues, with 10 players sidelined for the game.
John Mousinho is bolstered by some new faces for the game, however, with seven additions landed across the winter transfer window.
Here’s how Pompey writer, Jordan Cross, thinks Mousinho will go at Deepdale.
9. RW: Adrian Segecic
Gustavo Caballero's arrival may free Segecic up to vie for playing time through the middle - but it's the right flank for him for now. | Graham Hunt/ProSportsImages
10. CAM Conor Chaplin
Let that special moment against West Brom be the catalyst for a run of goalscoring form for Chaplin. | Graham Hunt/ProSportsImages
11. LW Keshi Anderson
Depending on how Mousinho's fills the void created by Bishop's absence, Anderson could well pick up his first start at Deepdale. Photo: Graham Hunt
12. CF: Millenic Alli
Could be Kirk or could even be Brown but Alli is fit, firing and led the line when Bishop was injured last weekend. | Graham Hunt/ProSportsImages