John Mousinho’s men are desperately trying to arrest a run of five games without a win, as they go to Loftus Road.
There’s big calls for the Pompey boss to make, as he looks to repeat successes on the road in the capital against Millwall and Charlton last month.
Here’s how Pompey writer Jordan Cross thinks the Blues head coach will go.
9. RW Gustavo Caballero
We've gone for Paraguayan returning to the right flank, where he needs to hit the best of some variable form. | Stephen Flynn/ProSportsImages
10. CAM John Swift
Pompey's best two results of the season have arrived with John Swift in the deep-lying attacking role. Makes sense to start him at Loftus Road. | Stephen Flynn/ProSportsImages
11. LW Millenic Alli
Form so variable at present - even across one game, but Alli looks Pompey's most potent attacking threat. | Stephen Flynn/ProSportsImages
12. ST: Colby Bishop
Taken out of the starting XI against Derby County. There was more mobility from Jacob Brown, but wasn't particularly successful. Bishop best suited for the physical battle with Ronnie Edwards and Jimmy Dunne. | Stephen Flynn/ProSportsImages