John Mousinho’s men are desperately trying to arrest a run of five games without a win, as they go to Loftus Road.
There’s big calls for the Pompey boss to make, as he looks to repeat successes on the road in the capital against Millwall and Charlton last month.
Here’s how Pompey writer Jordan Cross thinks the Blues head coach will go.
5. CB Connor Ogilvie
Probably looked more effective when switching to left-back Tuesday, but will be needed in the middle at Conor Shaughnessy's minutes are managed. | Stephen Flynn/ProSportsImages
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6. LB Zak Swanson
Will be looking to nail down a level of consistency over the coming weeks to keep his place in the team. | Getty Images
7. CM Ebou Adams
Observed Ramadan, with that period now over and the key midfielder looking to end the campaign in the forceful fashion we've grown accustomed to. | Getty Images
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8. CM Marlon Pack
Skipper set for eighth start on the spin as he turns 35 next week, with form strong across that period. | Stephen Flynn/ProSportsImages