After battling back to draw 2-2 with the Pilgrims, the Blues will be keen to pick up three points for the first time since victory over Shrewsbury Town in mid-August.
Since that success at Fratton Park, the Blues have recorded four defeats and one draw - with Tuesday’s stalemate preventing Cowley from suffering his worst run of league results as a manager.
The former Lincoln boss isn’t expected to chop and change his line-up for the trip to The Valley, as he’ll give the players who performed valiantly at Fratton Park another chance to shine.
Mahlon Romeo will be one to keep an eye on as he looks to maintain his impressive form on his return to south London.
5. Centre back 3 - Shaun Williams
Although Connor Ogilvie should return to fitness for the Chalrton fixture, Williams is expected to keep his place in the starting XI as a makeshift centre-back. It was the former Millwall midfielder's unfortunate error that led to Plymouth's second goal on Tuesday - a mistake that had Pompey staring at a fifth consecutive defeat before Raggett's timely intervention. Photo: JPIMedia
6. Right wing-back - Mahlon Romeo
Mahlon Romeo's glistening performances in Pompey colours has already brought him a number of admirers at Fratton Park. The Millwall loanee spoke in the week about how he's enjoying life on the south coast and will look to continue his strong form on his return to south London. Photo: JPIMedia
7. Central midfield - Joe Morrell
Joe Morrell enjoyed his best performance for Pompey in the draw with Plymouth and it's evident there's more to come from the Wales international. He returned to the starting XI last Tuesday after missing the loss to Cambridge due to a family bereavement. He dictated the tempo in midfield while applying the press expertly. Photo: JPIMedia
8. Central midfield - Ryan Tunnicliffe
Tunnicliffe returned to familiar surroundings on Tuesday when playing a deeper midfield role and is expected to operate from the same position against Charlton. The former Luton Town midfielder flourishes when driving with the ball from deep, before looking to play a killer pass. With three assists to his name so far this season, he is still Pompey's leading playmaker. Photo: JPIMedia