John Mousinho’s side face an in-form side at Stadium MK, with Mark Jackson overseeing an upturn in fortunes to drag his side away from the drop zone.
Pompey need to keep their impressive form under the new boss going, however, to up the pressure on the top six.
They have players coming back into the equation for the clash – here’s how we think they will line up.
9. CM - Ryan Tunnicliffe
Was used as the pivot/six/holding midfielder last weekend. May well be used further forward at MK. Alternative would be to go to a 4-2-3-1, in which case he'd vie for one of the two deeper roles. Photo: Jason Brown
10. RW - Owen Dale
After all his frustration, was pleasing to see Dale on the scoresheet last weekend. Could have bagged a couple more, but the challenge now is to keep up his output. Photo: Jason Brown
11. CF - Colby Bishop
MK Dons have acknowledged the Magic Man's threat and have said they will need to plan to stop him. As Mike Tyson once said, everyone has a plan until they get punched in the face... Photo: Jason Brown
12. LW Reeco Hackett
A slight knee issue kept Hackett out against Forest Green, but the winger had started the three previous games - with two coming on the road. Photo: Simon Davies