The new boss will be tempted to make a couple of changes because of the above.
But is now the right time to freshen things up?
Saying that, is there ever a good time when those you have called on have so far served you well?
We wait to see what Cowley decides.
In the meantime, though, here’s how we think the Blues will line up at Gresty Road this evening and why...
9. Left-wing - Ronan Curtis
The Republic of Ireland international has struggled in recent games as he's filled in for John Marquis up front. If Marquis returns to the team tonight, expect Curtis to head back to the left wing, where he can make a greater impact. Past couple of performances will have frustrated him, so he'll be like a coiled spring! Photo: JPIMedia
10. Centre-forward - Ryan Williams
The Aussie is such an important player for Pompey. His energy levels and commitment are just what Pompey need just now, especially when options up front are currently limited because of injuries. Just like some of his team-mates, a welcome break would do him the world of good. But needs must at the moment. Photo: JPIMedia
11. Centre-forward - John Marquis
The striker has been struggling with an ankle injury despite his recent three-match ban. There's doubts about his fitness going into tonight's game. But you suspect he'll play - especially after hearing the way new boss Danny Cowley speaks glowingly about him. Pompey have definitely missed a focal point up top in recent games. Photo: JPIMedia