Chiefly the Blues boss has to decide whether to go with John Marquis or George Hirst at Adams Park.
Hirst staked his claim with a man-of-the-match performance on Tuesday night as Marquis continues to struggle for form.
Elsewhere, there’s Arsenal’s Miguel Azeez pushing for a start with Cowley admitting he could be down to as few as 14 fit senior players.
Here’s how we believe the Pompey boss will line up as they face a tough test at the high-flying Chairboys.
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13. Toby Steward
Extremely promising youngster looks set for a place on the bench as Bass' deputy, Photo: Jason Brown
14. Kieron Freeman
Will offer cover across the back four with such a lack of defensive options. Photo: The News
15. Harry Jewitt-White
Really impressed in second half on Tuesday, and with Pompey struggling with injuries could stay involved. Photo: The News
16. Michael Jacobs
Did a decent job on Tuesday, but in reality will be back on the bench at Adams Park. Photo: The News