John Mousinho has been hit by injuries and suspensions going into the game, as his side look to maintain their sturdy start to the season.
But Chelsea new boy Tino Anjorin is in contention after joining on the eve of transfer deadine day.
Here’s how we think Pompey will line up as they go to Pride Park.
9. Paddy Lane
With Gavin Whyte struggling Lane looks set to start on the right after international duty with Northern Ireland. Photo: Jason Brown
10. ACM: Christian Saydee
In such impressive form, the striker looks certain to continue in his deep-lying striking role - or playing as a 10 if you'd rather frame it that way. Photo: Jason Brown
11. LW: Abu Kamara
Off the mark against Peterborough and with injuries in wide areas, the Norwich loanee looks set to continue against Paul Warne's side. Photo: Jason Brown
12. CF: Colby Bishop
The Magic Man is showing the kind of form which marks him out as arguably the division's top marksman. Photo: Jason Brown