John Mousinho has been hit by injuries and suspensions going into the game, as his side look to maintain their sturdy start to the season.
But Chelsea new boy Tino Anjorin is in contention after joining on the eve of transfer deadine day.
Here’s how we think Pompey will line up as they go to Pride Park.
5. LCB: Conor Shaughnessy
Has come through to make the spot on the left side his at the expense of Ryley Towler. Photo: Jason Brown
6. LB: Connor Ogilvie
No reason for Mr Dependable not to continue at Pride Park. Photo: Jason Brown
7. DCM: Marlon Pack
Could've gone to Derby - will be out to show he made the right decision at Pride Park. Photo: Jason Brown
8. ACM: Alex Robertson
Really interesting one. Does Mousinho go with one sitting midfielder in Pack and free Robertson to play further forward? Alternatively Ben Stevenson or Terry Devlin could sit deeper and stiffen things up. Photo: Jason Brown