It’s the Blues first trip to the CBS Arena since October 2018, when Ronan Curtis first-half strike continued Kenny Jackett’s men's impressive start to the 2018-19 League One season.
Now in the Championship, John Mousinho’s side will be looking to return to winning ways after Saturday’s 2-1 loss to Millwall.
The disappointment at The Den represented Pompey’s 14th away defeat of the campaign as they continue to struggle on their travels.
Nonetheless, that hasn’t deterred 2,300 members of the Fratton faithful from making the 280-mile round trip to the West Midlands.
The Sky Blues will be without boss Frank Lampard after he was given a one-game touchline ban following a red card against Burnley on Saturday.
With an exciting prospect ahead which could have repercussions at either end of the table, here’s the latest team news from both camps.
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5. Callum Lang - Out
Lang was Pompey’s hero in the 4-1 triumph against the Sky Blues in the reverse fixture between the two sides at Fratton Park in December. He remains absent for Mousinho’s men after a campaign-ending hamstring injury sustained against Oxford United in February. | Jason Brown/ProSportsImages
6. Oliver Dovin - Out
Dovin recently sustained an ACL injury and has subsequently been ruled out for the remainder of the campaign. The goalkeeper is expected to undergo surgery soon. | Getty Images
7. Rob Atkinson - Out
Atkinson was the biggest talking point from Mousinho’s pre-match press conference after the head coach confirmed the defender will return to training this week. Although the Bristol City loanee won’t feature at the CBS Arena, he is closing in on a comeback to the side after sustaining a calf issue in February. | Jason Brown/ProSportsImages
8. Josh Eccles - Out
Eccles has struggled with a calf strain, which Lampard confirmed is only minor. However, the 25-year-old will be out of tonight’s contest and is expected to make his comeback next week. | Getty Images