It's a tough assignment for John Mousinho's side against opposition with one of the best home records in the division.
The Blues are on a nine-game unbeaten run, however, as they aim to move a step closer to the Championship.
Here's how we think Pompey will line up, as they embark on the run-in with 10 games remaining.
5. CB Conor Shaughnessy
Everything we've said about Shaughnessy already this season continues to apply. Photo: Jason Brown
6. LB Connor Ogilvie
Like Shaughnessy, continues to do everything that Connor Ogilvie does. Photo: Jason Brown
7. CM Marlon Pack
Came through a real see-saw midfield battle with Oxford last weekend and will have his hands full once again - but has shown he's more than up to the task. Photo: Jason Brown
8. CM Owen Moxon
Interesting call for Mousinho to make with Myles Peart-Harris having a see-saw afternoon against Oxford. May be that the more solid attributes of Moxon over MPH's attacking quality may make sense on this occasion. Photo: Jason Brown